Chronic inflammatory polyneuropathy involves nerve swelling and irritation (inflammation) that leads to a loss of strength or sensation.

Immune or inflammatory mechanisms are implicated in a number of chronic disorders affecting the peripheral nerve. One of the more commonly  recognized is idiopathic chronic inflammatory demyelinating  polyneuropathy,  or  CIDP.  The  incidence  of  new  cases  of  CIDP  each  year  is estimated to  be between 1.5 and 3.6 per million population and, because of the chronicity of the disease, to affect as many as 40,000 patients in the United States at any one time. Although this  disorder  can affect  children  and  adults  of  any  age, the  peak  period  of  life during which patients develop CIDP is in the 6th and seventh decade and the disorder is twice as common in men as women. (Simmons et al,1997;van Schaik, 2008).

  • Symptoms:

    • Difficulty walking due to weakness
    • Difficulty using the arms and hands or legs and feet due to weakness
    • Facial weakness
    • Sensation changes (usually affects feet first, then the arms and hands)
    • Numbness or decreased sensation
    • Pain, burning, tingling, or other abnormal sensations
    • Weakness, usually in the arms and hands or legs and feet
    • Other symptoms that can occur with this disease:
    • Abnormal movement
    • Bowel or bladder problems
    • Breathing difficulty
    • Fatigue
    • Hoarseness or changing voice
    • Loss of function or feeling in the muscles
    • Muscle atrophy
    • Muscle contractions
    • Paralysis of the face
    • Speech impairment
    • Swallowing difficulty
    • Uncoordinated movement


Chronic inflammatory polyneuropathy leads to a common type of damage to nerves outside the brain or spinal cord (peripheral neuropathy). Polyneuropathy means several nerves are involved. It usually affects both sides of the body the same amount.

The cause of chronic inflammatory polyneuropathy is an abnormal immune response. The specific triggers vary. In many cases, the cause cannot be identified.

It may occur with other conditions, such as:

Chronic hepatitis                                            Diabetes                                           

Lymphoma                                                       Thyrotoxicosis

Inflammatory bowel disease                       HIV

Systemic lupus erythematosus

PMWO operates worlds largest mobile plasmapheresis network in Pakistan from Peshwar to Karachi & Quetta

Test & Diagnostic methods

The doctor will examine you and ask questions about your medical history. The physical exam shows:

Loss of muscle mass

No reflexes


Muscle weakness

Sensation problems on both sides of the body

Tests may include:

Electromyography (EMG)

Nerve conduction tests

Nerve biopsy

Spinal tap

Which other tests are done depends on the suspected cause of the condition, and may include x-rays, imaging scans, and blood tests.

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Low Cost Treatment

PMWO solved medicines problem permanently and manufactured world’s cheapest medicine in Pakistan for MG patients.

Growing Network

develop contacts with MG and GBS/CIDP organizations abroad to share information, views and experiences to discover the cure of MG

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PMWO has established a National Myasthenic Drug Bank for the distribution of Medicines, to poor patients of Myasthenia Gravis and GBS

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